Rnpc3^{tm1b(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Rnpc3^{tm1b(EUCOMM)Wtsi}
• Name: RNA-binding region (RNP1, RRM) containing 3; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:6276236
• Synonyms: Rnpc3^-
• Gene: Rnpc3 Location: Chr3:113398716-113423798 bp, - strand Genetic Position: Chr3, 49.35 cM, cytoband G1
• Alliance: Rnpc3^{tm1b(EUCOMM)Wtsi} page
• IMPC: Rnpc3 gene page

Mutation origin

• Mutant Cell Line: EPD0441_1_B10
• Germline Transmission: Earliest citation of germline transmission: J:267519
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Pgk_P
• Mutation details: Cre-mediated excision of the parental Rnpc3^{tm1a(EUCOMM)Wtsi} allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exons 4 and 5 leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:267519)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnpc3 Mutation: 41 strains or lines available

References

• Original: J:267519 Doggett K, et al., Early developmental arrest and impaired gastrointestinal homeostasis in U12-dependent splicing-defective Rnpc3-deficient mice. RNA. 2018 Dec;24(12):1856-1870
• All: 1 reference(s)