Tg(CAG-Ncoa6)84Hwl
Transgene Detail

Summary

• Symbol: Tg(CAG-Ncoa6)84Hwl
• Name: transgene insertion 84, Han-Woong Lee
• MGI ID: MGI:6276320
• Synonyms: DN1
• Transgene: Tg(CAG-Ncoa6)84Hwl Location: unknown
• Alliance: Tg(CAG-Ncoa6)84Hwl page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-Ncoa6)84Hwl expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Ncoa6

• Mutation details: This transgene consists of a hemagglutinin (HA)-tagged fragment of Ncoa6 encoding amino acids 849-929 under the control of the chicken beta-actin promoter linked to a human cytomegalovirus immediate-early enhancer (CAG). This Ncoa6 fragment encompasses the N-terminal LXXLL motif (called DN1) and has a strong dominant negative effect on transactivation by retinoid and other nuclear receptors. This line shows transgene expression in the eye, heart, and brain. (J:80609)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:80609 Kim SW, et al., Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract. Mol Cell Biol. 2002 Dec;22(24):8409-14
• All: 2 reference(s)