About   Help   FAQ
Tg(CAG-Ncoa6)104Hwl
Transgene Detail
Summary
Symbol: Tg(CAG-Ncoa6)104Hwl
Name: transgene insertion 104, Han-Woong Lee
MGI ID: MGI:6276322
Synonyms: DN1
Transgene: Tg(CAG-Ncoa6)104Hwl  Location: unknown  
Alliance: Tg(CAG-Ncoa6)104Hwl page
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CAG-Ncoa6)104Hwl expresses 1 gene
 
Mutation detailsThis transgene consists of a hemagglutinin (HA)-tagged fragment of Ncoa6 encoding amino acids 849-929 under the control of the chicken beta-actin promoter linked to a human cytomegalovirus immediate-early enhancer (CAG). This Ncoa6 fragment encompasses the N-terminal LXXLL motif (called DN1) and has a strong dominant negative effect on transactivation by retinoid and other nuclear receptors. This line shows transgene expression in the respiratory tract, liver, thymus, spleen, gall bladder, kidney, and adrenal gland and high expression in the heart. (J:80609)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:80609 Kim SW, et al., Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract. Mol Cell Biol. 2002 Dec;22(24):8409-14
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/22/2024
MGI 6.24
The Jackson Laboratory