Ttc19^em1Bds
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ttc19^em1Bds
• Name: tetratricopeptide repeat domain 19; endonuclease-mediated mutation 1, Bart De Strooper
• MGI ID: MGI:6276545
• Gene: Ttc19 Location: Chr11:62172256-62208611 bp, + strand Genetic Position: Chr11, 38.02 cM
• Alliance: Ttc19^em1Bds page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 1, encoding the mitochondrial sorting motif, deleted 5 nucleotides downstream of the translation initiation site. (J:269785)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ttc19 Mutation: 14 strains or lines available

References

• Original: J:269785 Spinazzi M, et al., PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):277-286
• All: 2 reference(s)