Trdc^{tm1(EGFP/HBEGF/luc)Impr}
Targeted Allele Detail

Summary

• Symbol: Trdc^{tm1(EGFP/HBEGF/luc)Impr}
• Name: T cell receptor delta, constant region; targeted mutation 1, Immo Prinz
• MGI ID: MGI:6276620
• Synonyms: Tcrd-GDL, Trdc^{tm1(eGFP-2A-hDTR- 2A-CBGr99 luciferase)Impr}
• Gene: Trdc Location: Chr14:54380308-54383565 bp, + strand Genetic Position: Chr14, 27.66 cM
• Alliance: Trdc^{tm1(EGFP/HBEGF/luc)Impr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269697
• Parent Cell Line: JM8A3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Trdc^{tm1(EGFP/HBEGF/luc)Impr} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

  Fused with an EGFP reporter gene

• Mutation details: The targeting vector introduced into the 3' UTR an IRES, EGFP reporter gene, human HBEGF (DTR) gene and luciferase reporter gene. (J:269697)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trdc Mutation: 7 strains or lines available

References

• Original: J:269697 Sandrock I, et al., Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing gammadelta T cells. J Exp Med. 2018 Dec 3;215(12):3006-3018
• All: 8 reference(s)