Luc7l^em1(IMPC)Mbp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Luc7l^em1(IMPC)Mbp
• Name: Luc7-like; endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• MGI ID: MGI:6277019
• Gene: Luc7l Location: Chr17:26471870-26504478 bp, + strand Genetic Position: Chr17, 13.09 cM, cytoband B1
• Alliance: Luc7l^em1(IMPC)Mbp page
• IMPC: Luc7l gene page

Mutation origin

• Strain of Origin: C57BL/6NCrl
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele from IMPC was generated at UC Davies by injecting CAS9 Protein and 2 guide sequences ATGTGAACATACCCAGACACCGG, TCTGTTCTGCGAATTAACGGTGG, which resulted in a Exon Deletion. (J:265051)
• Inheritance: Not Specified

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Luc7l^em1(IMPC)Mbp/Luc7l^em1(IMPC)Mbp	C57BL/6N-Luc7l^em1(IMPC)Mbp/MbpMmucd

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms Sex:
Source:	IMPC - UCD	IMPC - UCD
cardiovascular system	√	√
enlarged heart		√
small heart	√
growth/size/body	√	√
enlarged heart		√
enlarged kidney	√	√
enlarged liver		√
enlarged spleen	√	√
hematopoietic system	√	√
increased erythrocyte cell number	√
abnormal spleen morphology	√	√
enlarged spleen	√	√
immune system	√	√
abnormal spleen morphology	√	√
enlarged spleen	√	√
enlarged lymph nodes		√
integument	√	√
abnormal coat/hair pigmentation		√
abnormal skin morphology	√	√
liver/biliary system	√	√
abnormal liver morphology	√	√
enlarged liver		√
pigmentation		√
abnormal coat/hair pigmentation		√
renal/urinary system	√	√
abnormal kidney morphology	√
enlarged kidney	√	√
small kidney	√
vision/eye	√
abnormal eye morphology	√
microphthalmia	√
anophthalmia	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Luc7l Mutation: 35 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 3 reference(s)