Nrg3^tm1.1Plet
Targeted Allele Detail

Summary

• Symbol: Nrg3^tm1.1Plet
• Name: neuregulin 3; targeted mutation 1.1, Mikhail Pletnikov
• MGI ID: MGI:6277991
• Synonyms: Nrg3^-
• Gene: Nrg3 Location: Chr14:38090909-39195045 bp, - strand Genetic Position: Chr14, 22.18 cM, cytoband B
• Alliance: Nrg3^tm1.1Plet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270199
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted to flank exon 2, and an frt-flanked neomycin selection cassette was inserted between the 5' loxP site and exon 2. Cre-mediated recombination removed the neomycin cassette and exon 2. Northern blot analysis of whole brain RNA showed that the transcript was not present in homozygous mutant mice. (J:270199)

Disease models

Expression

In Mice Carrying this Mutation:

10 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrg3 Mutation: 54 strains or lines available

References

• Original: J:270199 Hayes LN, et al., Neuregulin 3 Knockout Mice Exhibit Behaviors Consistent with Psychotic Disorders. Mol Neuropsychiatry. 2016 Jul;2(2):79-87
• All: 2 reference(s)