Tg(Actb-Ptma)T12Clwu
Transgene Detail

Summary

• Symbol: Tg(Actb-Ptma)T12Clwu
• Name: transgene insertion T12, Chao-Liang Wu
• MGI ID: MGI:6278014
• Synonyms: ProT
• Transgene: Tg(Actb-Ptma)T12Clwu Location: unknown
• Alliance: Tg(Actb-Ptma)T12Clwu page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Actb-Ptma)T12Clwu expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ptma (MGI:97803)

• Mutation details: The transgene contains the complete 1.2 kb murine prothymosin alpha cDNA under the control of the rat beta-actin promoter. RT-PCR confirmed expression of the transgene in all organs examined, including spleen, thymus, lung, liver and kidney. Two lines were generated, T9 and T12. Line T12 is entered as the representative line. (J:128557)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:128557 Li KJ, et al., Transgenic overexpression of prothymosin alpha induces development of polycystic kidney disease. Kidney Int. 2005 May;67(5):1710-22
• All: 5 reference(s)