Arc^tm1.1Rpa
Targeted Allele Detail

Summary

• Symbol: Arc^tm1.1Rpa
• Name: activity regulated cytoskeletal-associated protein; targeted mutation 1.1, Richard D Palmiter
• MGI ID: MGI:6278157
• Synonyms: Arc^lox
• Gene: Arc Location: Chr15:74540932-74544419 bp, - strand Genetic Position: Chr15, 34.25 cM
• Alliance: Arc^tm1.1Rpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269999
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was introduced to the promoter region and a loxP-FRT-neomycin-FRT cassette was placed in the first intron downstream of the first exon. Flp-mediated recombination removed the FRT-flanked neo cassette leaving the coding region floxed. (J:269999)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Arc Mutation: 33 strains or lines available

References

• Original: J:269999 Chen JY, et al., Parabrachial CGRP Neurons Establish and Sustain Aversive Taste Memories. Neuron. 2018 Nov 21;100(4):891-899.e5
• All: 3 reference(s)