Atp2b1^{Tg(Thy1-CHMP2B*)1Rene}
Transgenic Allele Detail

Summary

• Symbol: Atp2b1^{Tg(Thy1-CHMP2B*)1Rene}
• Name: ATPase, Ca++ transporting, plasma membrane 1; transgene insertion 1, Frederique Rene
• MGI ID: MGI:6278934
• Synonyms: CHMP2B^intron5
• Gene: Atp2b1 Location: Chr10:98750268-98862005 bp, + strand Genetic Position: Chr10, 50.97 cM, cytoband C3
• Alliance: Atp2b1^{Tg(Thy1-CHMP2B*)1Rene} page

Transgene origin

• Strain of Origin: (FVB/N x (C57BL/6J x DBA/2J))F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Atp2b1^{Tg(Thy1-CHMP2B*)1Rene} expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CHMP2B (25978)

  Chmp2b

  (MGI:1916192)

  contains a mutation identified in human familial FTD that results in truncation at the carboxy terminus

• Mutation details: The human CHMP2B cDNA containing a missense mutation in the splice acceptor site of exon 6 that is a mutation identified in human familial FTD, and tagged with two hemagglutinin sequences, is under the control of the mouse Thy1.2 promoter. The transgene integrated within chromosome 10: 98950250-98968278 in the Atp1b1 gene within the large first intron. Atp2b1 mRNA levels are not modified although a trend of a decrease is seen in homozygous mice. One line was established. (J:237873)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp2b1 Mutation: 66 strains or lines available

References

• Original: J:237873 Vernay A, et al., A transgenic mouse expressing CHMP2Bintron5 mutant in neurons develops histological and behavioural features of amyotrophic lateral sclerosis and frontotemporal dementia. Hum Mol Genet. 2016 Aug 01;25(15):3341-3360
• All: 2 reference(s)