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Map3k3tm1.2Mlkn
Targeted Allele Detail
Summary
Symbol: Map3k3tm1.2Mlkn
Name: mitogen-activated protein kinase kinase kinase 3; targeted mutation 1.2, Mark Kahn
MGI ID: MGI:6279294
Gene: Map3k3  Location: Chr11:105975439-106046272 bp, + strand  Genetic Position: Chr11, 68.89 cM
Alliance: Map3k3tm1.2Mlkn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:238897
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 9. An F3-flanked puromycin resistance cassette with a 3' loxP site was inserted downstream of exon 15. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination deleted exons 9-15. (J:238897)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map3k3 Mutation:  27 strains or lines available
Notes
ES cell line = Art B6.3.5 (C57BL/6NTac)
References
Original:  J:238897 Zhou Z, et al., The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression. Dev Cell. 2015 Jan 26;32(2):168-80
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory