Ercc6l^tm1.2Ajlc
Targeted Allele Detail

Summary

• Symbol: Ercc6l^tm1.2Ajlc
• Name: excision repair cross-complementing rodent repair deficiency complementation group 6 like; targeted mutation 1.2, Andres J Lopez-Contreras
• MGI ID: MGI:6280030
• Synonyms: Pich^-
• Gene: Ercc6l Location: ChrX:101186426-101200697 bp, - strand Genetic Position: ChrX, 45.16 cM
• Alliance: Ercc6l^tm1.2Ajlc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271028
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was flanked by loxP sites, with one loxP site positioned inside the 3' UTR of exon 2. A FRT-flanked neomycin cassette that was inserted between the first loxP site and exon 2 was removed via flp-mediated recombination. Cre-mediated recombination deleted the exon 2 open reading frame. Immunohistochemistry confirmed the absence of protein in hemizygous male embryos at E10.5. (J:271028)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ercc6l Mutation: 6 strains or lines available

References

• Original: J:271028 Albers E, et al., Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality. Cell Rep. 2018 Sep 18;24(12):3274-3284
• All: 1 reference(s)