Tg(Clec4g-icre)1.1Sgoe
Transgene Detail

Summary

• Symbol: Tg(Clec4g-icre)1.1Sgoe
• Name: transgene insertion 1.1, Sergij Goerdt
• MGI ID: MGI:6280453
• Synonyms: Clec4g-Cre, Tg(Clec4g-cre)1.1
• Transgene: Tg(Clec4g-icre)1.1Sgoe Location: unknown
• Alliance: Tg(Clec4g-icre)1.1Sgoe page

Transgene origin

• Strain of Origin: C57BL/6NCrl

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Clec4g-icre)1.1Sgoe expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Clec4g (MGI:1923113)

• Mutation details: A cDNA containing a codon improved version of cre recombinase followed by polyA signal sequence was fused in frame into a BAC clone (RPCI-23-239-A7) at exon 1 of mouse Clec4g so that cre expression is driven by the regulatory sequences of the BAC gene. The resulting modified BAC was used to generate this transgene. Three founder lines 1.1, 1.2 and 1.3 were identified. (J:271085)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Clec4g (mouse) Summary of all recombinase alleles driven by Clec4g. Comparative matrix view of recombinase activities Alliance mouse Clec4g gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:271085 Wohlfeil SA, et al., Hepatic Endothelial Notch Activation Protects against Liver Metastasis by Regulating Endothelial-Tumor Cell Adhesion Independent of Angiocrine Signaling. Cancer Res. 2019 Feb 1;79(3):598-610
• All: 3 reference(s)