Hip1^{tm5.2(HIP1)Tsr}
Targeted Allele Detail

Summary

• Symbol: Hip1^{tm5.2(HIP1)Tsr}
• Name: huntingtin interacting protein 1; targeted mutation 5.2, Theodora S Ross
• MGI ID: MGI:6280492
• Synonyms: Hip1^HIP1
• Gene: Hip1 Location: Chr5:135435385-135573974 bp, - strand Genetic Position: Chr5, 75.18 cM, cytoband F-G2
• Alliance: Hip1^{tm5.2(HIP1)Tsr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267987
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout, Reporter)
• Mutation: Insertion
• Hip1^{tm5.2(HIP1)Tsr} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HIP1 (3092)

  Hip1	(MGI:1099804)

• Mutation details: Cre-mediated recombination removed LSL-STOP sequence from Hip1^{tm5.1(HIP1)Tsr} resulting in expression human HIP1 and a GFP reporter. GFP expression was detected in peripheral blood white blood cells of homozygous mutant mice. Western blot analysis confirmed the expression of human, rather than mouse, HIP1 protein in lung tissue from homozygous mutant mice. (J:267987)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hip1 Mutation: 67 strains or lines available

References

• Original: J:267987 Wijayatunge R, et al., Deficiency of the Endocytic Protein Hip1 Leads to Decreased Gdpd3 Expression, Low Phosphocholine, and Kypholordosis. Mol Cell Biol. 2018 Dec 1;38(23)
• All: 1 reference(s)