Gimap5^tm1Yout
Targeted Allele Detail

Summary

• Symbol: Gimap5^tm1Yout
• Name: GTPase, IMAP family member 5; targeted mutation 1, Yousuke Takahama
• MGI ID: MGI:6280692
• Gene: Gimap5 Location: Chr6:48723131-48731134 bp, + strand Genetic Position: Chr6, 23.71 cM
• Alliance: Gimap5^tm1Yout page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209926
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site flanked inverted neomycin resistance gene cassette replaced 36 bps, from -1 bp through +35 bp relative to the coding sequence, including the start codon. Western blot analysis with an anti-Gimap5 antibody that binds to a truncated protein lacking N-terminal 10 or 26 amino acids indicates that truncated protein is not produced. (J:209926)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gimap5 Mutation: 13 strains or lines available

References

• Original: J:209926 Yano K, et al., Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse. Eur J Immunol. 2014 Feb;44(2):561-72
• All: 1 reference(s)