Clptm1l^{tm1d(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Clptm1l^{tm1d(EUCOMM)Wtsi}
• Name: CLPTM1-like; targeted mutation 1d, Wellcome Trust Sanger Institute
• MGI ID: MGI:6281109
• Synonyms: Clptm1l^del
• Gene: Clptm1l Location: Chr13:73752125-73768724 bp, + strand Genetic Position: Chr13, 40.12 cM
• Alliance: Clptm1l^{tm1d(EUCOMM)Wtsi} page
• IMPC: Clptm1l gene page

Mutation origin

• Mutant Cell Line: EPD0460_2_E07
• Germline Transmission: Earliest citation of germline transmission: J:265892
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: Cre-mediated recombination of Clptm1l^{tm1c(EUCOMM)Wtsi} removed exon 3, creating a frame shift mutation with a stop codon immediately downstream. No mRNA transcripts were detected in lipopolysaccharide (LPS) stimulated B cell cultures from homozygous mutant mice. Interestingly, the abundance of mRNA was greater in heterozygous B cell cultures than in wild-type cultures. (J:265892)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clptm1l Mutation: 34 strains or lines available

References

• Original: J:265892 Trezise S, et al., Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins. Int J Mol Sci. 2018 Jul 24;19(8):2161
• All: 1 reference(s)