Tet3^tm1.1Yzhg
Targeted Allele Detail

Summary

• Symbol: Tet3^tm1.1Yzhg
• Name: tet methylcytosine dioxygenase 3; targeted mutation 1.1, Yi Zhang
• MGI ID: MGI:6281584
• Synonyms: Tet3^f
• Gene: Tet3 Location: Chr6:83339355-83434190 bp, - strand Genetic Position: Chr6, 35.94 cM
• Alliance: Tet3^tm1.1Yzhg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271344
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 7. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 9. Flp-mediated recombination removed the selection cassette and left exons 7 through 9 floxed. (J:271344)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tet3 Mutation: 60 strains or lines available

References

• Original: J:271344 Shen L, et al., Tet3 and DNA replication mediate demethylation of both the maternal and paternal genomes in mouse zygotes. Cell Stem Cell. 2014 Oct 2;15(4):459-471
• All: 5 reference(s)