Rab10tm1c(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Rab10tm1c(KOMP)Wtsi |
Name: |
RAB10, member RAS oncogene family; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:6281610 |
Synonyms: |
Rab10fl |
Gene: |
Rab10 Location: Chr12:3297428-3359969 bp, - strand Genetic Position: Chr12, 1.71 cM
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Alliance: |
Rab10tm1c(KOMP)Wtsi page
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IMPC: |
Rab10 gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:249843
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: The L1L2_Bact_P cassette was inserted at position 3314374 of Chromosome 12 upstream of the critical exon 1 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon at position 3315039. The critical exon 1 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:249843)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rab10 Mutation: |
26 strains or lines available
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Original: |
J:249843 Vazirani RP, et al., Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance. Diabetes. 2016 Jun;65(6):1577-89 |
All: |
2 reference(s) |
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