Prorp^tm1.2Afi
Targeted Allele Detail

Summary

• Symbol: Prorp^tm1.2Afi
• Name: protein only RNase P catalytic subunit; targeted mutation 1.2, Aleksandra Filipovska
• MGI ID: MGI:6281700
• Gene: Prorp Location: Chr12:55349422-55429276 bp, + strand Genetic Position: Chr12, 23.91 cM, cytoband C1
• Alliance: Prorp^tm1.2Afi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238964
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked puromycin resistance cassette with a 3' loxP site. Flp-mediated recombination removed the selection cassette and left exon 3 floxed. Cre-mediated recombination removed exon 3. (J:238964)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prorp Mutation: 46 strains or lines available

References

• Original: J:238964 Rackham O, et al., Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly. Cell Rep. 2016 Aug 16;16(7):1874-90
• All: 1 reference(s)