Pomc^tm1.1Kgm
Targeted Allele Detail

Summary

• Symbol: Pomc^tm1.1Kgm
• Name: pro-opiomelanocortin-alpha; targeted mutation 1.1, Kathleen Mountjoy
• MGI ID: MGI:6282893
• Synonyms: ACTH^QKQR
• Gene: Pomc Location: Chr12:4004951-4010642 bp, + strand Genetic Position: Chr12, 1.99 cM
• Alliance: Pomc^tm1.1Kgm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263640
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Targeting inserted a modified exon 3 in which the coding sequence was modified from coding the amino acid proteolytic cleavage site sequence KKRR to QKQR. Cre-mediated recombination removed the floxed neomycin resistance cassette and the endogenous exon 3. (J:263640)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pomc Mutation: 21 strains or lines available

References

• Original: J:263640 Mountjoy KG, et al., Desacetyl-alpha-melanocyte stimulating hormone and alpha-melanocyte stimulating hormone are required to regulate energy balance. Mol Metab. 2018 Mar;9:207-216
• All: 4 reference(s)