Elmo1^M4Btlr
Chemically induced Allele Detail

Summary

• Symbol: Elmo1^M4Btlr
• Name: engulfment and cell motility 1; mutation 4, Bruce Beutler
• MGI ID: MGI:6283500
• Synonyms: Dollie
• Gene: Elmo1 Location: Chr13:20274766-20792523 bp, + strand Genetic Position: Chr13, 7.21 cM, cytoband A3.1
• Alliance: Elmo1^M4Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced G to T transversion at base pair 20,572,446 (v38) on chromosome 13, or base pair 481,940 in the GenBank genomic region NC_000079 encoding Elmo1. The mutation corresponds to residue 2,041 in the mRNA sequence NM_080288 within exon 18 of 22 total exons. The mutation results in an arginine to leucine substitution at position 568 (R568L) in the ELMO1 protein. (J:271969)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elmo1 Mutation: 59 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=4104

References

• Original: J:271969 Zhong X, et al., Mutagenetix entry for Dollie. MGI Direct Data Submission. 2019
• All: 1 reference(s)