Tcf12^M3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tcf12^M3Btlr
• Name: transcription factor 12; mutation 3, Bruce Beutler
• MGI ID: MGI:6283517
• Synonyms: Poorly3
• Gene: Tcf12 Location: Chr9:71751534-72019611 bp, - strand Genetic Position: Chr9, 39.85 cM
• Alliance: Tcf12^M3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 72,015,636 (v38) on chromosome 9, or base pair 96,184 in the GenBank genomic region NC_000075 within the splice donor site of intron 4. The effect of the mutation at the cDNA and protein levels has not been examined, but the mutation is predicted to result in skipping of the 74-base pair exon 4. The mutation would cause a frame-shifted protein product beginning after amino acid 50 of the protein, which is normally 706 amino acids in length, and termination after the inclusion of eight aberrant amino acids. (J:271971)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf12 Mutation: 75 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3616

References

• Original: J:271971 Zhong X, et al., Mutagenetix entry for Poorly3. MGI Direct Data Submission. 2019
• All: 1 reference(s)