Mamdc2em1(IMPC)J
Endonuclease-mediated Allele Detail
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Symbol: |
Mamdc2em1(IMPC)J |
Name: |
MAM domain containing 2; endonuclease-mediated mutation 1, Jackson |
MGI ID: |
MGI:6283570 |
Gene: |
Mamdc2 Location: Chr19:23279973-23425806 bp, - strand Genetic Position: Chr19, 18.22 cM
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Alliance: |
Mamdc2em1(IMPC)J page
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IMPC: |
Mamdc2 gene page |
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Strain of Origin: |
C57BL/6NJ
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Project Collection: |
IMPC
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Allele Type: |
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Endonuclease-mediated (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences CATGTGTTCTATGCTATATG and CTTGCATTGCATCATCCCAA, which resulted in a 446 bp deletion beginning at Chromosome 19 position 23,378,605 bp and ending after 23,379,050 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000349008 (exon 3) and 174 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 49 and early truncation 13 amino acids later. There is a single bp (T) insertion at the deletion site.
(J:188991)
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Inheritance: |
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Not Specified |
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012; |
All: |
3 reference(s) |
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