Pappa2^M5Btlr
Chemically induced Allele Detail

Summary

• Symbol: Pappa2^M5Btlr
• Name: pappalysin 2; mutation 5, Bruce Beutler
• MGI ID: MGI:6283613
• Synonyms: Gulliver
• Gene: Pappa2 Location: Chr1:158539297-158788019 bp, - strand Genetic Position: Chr1, 68.49 cM
• Alliance: Pappa2^M5Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced C to T transition at base pair 158,857,136 (v38) on chromosome 1, or base pair 123,392 in the GenBank genomic region NC_000067. The mutation corresponds to residue 2,432 in the mRNA sequence NM_001085376 within exon 4 of 22 total exons. The mutation results in a threonine to isoleucine substitution at position 811 (T811I) in the PAPP-A2 protein. (J:271980)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pappa2 Mutation: 88 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3805

References

• Original: J:271980 Zhang Z, et al., Mutagenetix entry for Gulliver. MGI Direct Data Submission. 2019
• All: 1 reference(s)