Cdh17^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Cdh17^M1Btlr
• Name: cadherin 17; mutation 1, Bruce Beutler
• MGI ID: MGI:6283871
• Synonyms: Disruptive
• Gene: Cdh17 Location: Chr4:11758157-11817905 bp, + strand Genetic Position: Chr4, 5.35 cM, cytoband A2
• Alliance: Cdh17^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: A to G transition at base pair 11,784,654 (v38) on chromosome 4, or base pair 26,498 in the GenBank genomic region NC_000070 encoding Cdh17. The mutation corresponds to residue 956 (c.956A>G) in the mRNA sequence NM_019753.4 within exon 8 of 18 total exons. The mutation results in a tyrosine to cysteine substitution at position 270 (p.Y270C) in the CDH17 protein. (J:272090)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh17 Mutation: 45 strains or lines available

References

• Original: J:272090 Turer E, et al., Mutagenetix entry for Disruptive. MGI Direct Data Submission. 2019
• All: 1 reference(s)