Card11^M6Btlr
Chemically induced Allele Detail

Summary

• Symbol: Card11^M6Btlr
• Name: caspase recruitment domain family, member 11; mutation 6, Bruce Beutler
• MGI ID: MGI:6283989
• Synonyms: Sharp
• Gene: Card11 Location: Chr5:140858745-140986337 bp, - strand Genetic Position: Chr5, 79.42 cM
• Alliance: Card11^M6Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced C to T transition at base pair 140,876,425 (v38) on chromosome 5, or base pair 124,172 in the GenBank genomic region NC_000071 encoding Card11. The mutation corresponds to residue 3,437 in the mRNA sequence NM_175362 within exon 23 of 25 total exons. The mutation results in a proline to leucine substitution at position 1,039 (P1039L) in the CARMA1 protein. (J:272116)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Card11 Mutation: 59 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3708

References

• Original: J:272116 Zhong X, et al., Mutagenetix entry for Sharp. MGI Direct Data Submission. 2019
• All: 1 reference(s)