Nfkb1^M5Btlr
Chemically induced Allele Detail

Summary

• Symbol: Nfkb1^M5Btlr
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105; mutation 5, Bruce Beutler
• MGI ID: MGI:6283996
• Synonyms: Frisbee
• Gene: Nfkb1 Location: Chr3:135290416-135397308 bp, - strand Genetic Position: Chr3, 62.82 cM
• Alliance: Nfkb1^M5Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced G to A transition at base pair 135,613,943 (v38) on chromosome 3, or base pair 78,040 in the GenBank genomic region NC_000069 encoding Nfkb1. The mutation corresponds to residue 1,292 in the mRNA sequence NM_008689 within exon 10 of 25 total exons. The mutation results in a glutamic acid to lysine substitution at position 264 (E264K) in the NFKB1 protein. (J:272117)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfkb1 Mutation: 102 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3794

References

• Original: J:272117 Zhong X, et al., Mutagenetix entry for Frisbee. MGI Direct Data Submission. 2019
• All: 1 reference(s)