Rec114^{tm1.2(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Rec114^{tm1.2(KOMP)Wtsi}
• Name: REC114 meiotic recombination protein; targeted mutation 1.2, Wellcome Trust Sanger Institute
• MGI ID: MGI:6284008
• Synonyms: Rec114^del
• Gene: Rec114 Location: Chr9:58560133-58651247 bp, - strand Genetic Position: Chr9, 31.79 cM, cytoband C
• Alliance: Rec114^{tm1.2(KOMP)Wtsi} page
• IMPC: Rec114 gene page

Mutation origin

• Mutant Cell Line: EPD0392_4_D08
• Germline Transmission: Earliest citation of germline transmission: J:271216
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: Flp-mediated excision of the parental Rec114^{tm1(KOMP)Wtsi} allele resulted in the removal of both the lacZ reporter sequence and the neomycin selection cassette. (J:271216)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rec114 Mutation: 14 strains or lines available

References

• Original: J:271216 Kumar R, et al., Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4. Life Sci Alliance. 2018 Dec;1(6):e201800259
• All: 1 reference(s)