Nfkb1^M6Btlr
Chemically induced Allele Detail

Summary

• Symbol: Nfkb1^M6Btlr
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105; mutation 6, Bruce Beutler
• MGI ID: MGI:6284012
• Synonyms: Wheelo
• Gene: Nfkb1 Location: Chr3:135290416-135397308 bp, - strand Genetic Position: Chr3, 62.82 cM
• Alliance: Nfkb1^M6Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced C to T transition at base pair 135,615,349 (v38) on chromosome 3, or base pair 76,634 in the GenBank genomic region NC_000069. The mutation corresponds to residue 1,146 in the mRNA sequence NM_008689 within exon 9 of 25 total exons. The mutation results in a threonine to isoleucine substitution at position 215 (T215I) in the NF-B1 protein. (J:272148)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfkb1 Mutation: 102 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3793

References

• Original: J:272148 SoRelle J, et al., Mutagenetix entry for Wheelo. MGI Direct Data Submission. 2019
• All: 1 reference(s)