Pcdhg^em41Rwb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pcdhg^em41Rwb
• Name: protocadherin gamma cluster; endonuclease-mediated mutation 41, Robert W Burgess
• MGI ID: MGI:6284353
• Synonyms: C4KO
• Gene: Pcdhg Location: unknown Genetic Position: Chr18, Syntenic

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Pcdhg^em41Rwb involves 1 genes/genome features (Pcdhgc4) View all
• Mutation details: This CRISPR/Cas9 mediated allele has a 13bp deletion (TACGTTTATGGGC) in variable exon C4 from coding base pair 85-97, causing a frameshift beginning at amino acid 29 of C4, but no other exons are mutated. (J:285314)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcdhg Mutation: 13 strains or lines available

References

• Original: J:285314 Garrett AM, et al., CRISPR/Cas9 interrogation of the mouse Pcdhg gene cluster reveals a crucial isoform-specific role for Pcdhgc4. PLoS Genet. 2019 Dec;15(12):e1008554
• All: 1 reference(s)