Ndnf^{tm1.1(cre)Rudy}
Targeted Allele Detail

Summary

• Symbol: Ndnf^{tm1.1(cre)Rudy}
• Name: neuron-derived neurotrophic factor; targeted mutation 1.1, Bernardo Rudy
• MGI ID: MGI:6284835
• Synonyms: NDNF-Cre, NDNF-ires-Cre
• Gene: Ndnf Location: Chr6:65648595-65689307 bp, + strand Genetic Position: Chr6, 30.29 cM
• Alliance: Ndnf^{tm1.1(cre)Rudy} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269094
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Ndnf^{tm1.1(cre)Rudy} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ndnf (MGI:1915419)

• Mutation details: The targeting vector contained, from 5' to 3', an internal ribosome entry site sequence (IRES; allows translation initiation in the middle of an mRNA sequence), the Cre recombinase sequence, a bovine growth hormone polyA sequence and a frt-flanked PGK-Neo-bGHpA cassette. Chimeric mice were bred to FLPe mice for germline removal of the PGK-Neo-bGHpA cassette. (J:269094)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ndnf (mouse) Summary of all recombinase alleles driven by Ndnf. Comparative matrix view of recombinase activities Alliance mouse Ndnf gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ndnf Mutation: 28 strains or lines available

References

• Original: J:269094 Schuman B, et al., Four Unique Interneuron Populations Reside in Neocortical Layer 1. J Neurosci. 2019 Jan 2;39(1):125-139
• All: 5 reference(s)