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Dock2m13Btlr
Chemically induced Allele Detail
Summary
Symbol: Dock2m13Btlr
Name: dedicator of cyto-kinesis 2; mutation 13, Bruce Beutler
MGI ID: MGI:6285149
Synonyms: skiff
Gene: Dock2  Location: Chr11:34176815-34674719 bp, - strand  Genetic Position: Chr11, 19.68 cM, cytoband A5
Alliance: Dock2m13Btlr page
Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Mutation
description
Allele Type:    Chemically induced (ENU) (Not Specified)
Mutation:    Single point mutation
 
Mutation detailsENU-induced A to G transition at base pair 34,262,388 (v38) on chromosome 11, or base pair 521,522 in the GenBank genomic region NC_000077 for Dock2. The mutation corresponds to residue 3,834 in the mRNA sequence NM_178666 within exon 37 of 52 total exons. The mutation results in a lysine to arginine substitution at position 1,251 (K1251R) in the DOCK2 protein. (J:272437)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dock2 Mutation:  143 strains or lines available
Notes
https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=4069
References
Original:  J:272437 Zhong X, et al., Mutagenetix entry for skiff. MGI Direct Data Submission. 2019;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory