Prkdc^M16Btlr
Chemically induced Allele Detail

Summary

• Symbol: Prkdc^M16Btlr
• Name: protein kinase, DNA activated, catalytic polypeptide; mutation 16, Bruce Beutler
• MGI ID: MGI:6285484
• Synonyms: Tweetie
• Gene: Prkdc Location: Chr16:15455730-15660099 bp, + strand Genetic Position: Chr16, 10.09 cM, cytoband B1
• Alliance: Prkdc^M16Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to A transition at base pair 15,717,801 (v38) on chromosome 16, or base pair 80,359 in the GenBank genomic region NC_000082 for Prkdc. The mutation corresponds to residue 5,047 in the mRNA sequence NM_011159 within exon 38 of 86 total exons. The mutation results in a leucine to glutamine substitution at position 1,675 (L1675Q) in the DNA-PKCS protein. (J:272520)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkdc Mutation: 417 strains or lines available

References

• Original: J:272520 Zhong X, et al., Mutagenetix entry for Tweetie. MGI Direct Data Submission. 2019
• All: 1 reference(s)