Tg^m4Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tg^m4Btlr
• Name: thyroglobulin; mutation 4, Bruce Beutler
• MGI ID: MGI:6285492
• Synonyms: samarai
• Gene: Tg Location: Chr15:66542606-66722570 bp, + strand Genetic Position: Chr15, 29.3 cM, cytoband D3-E
• Alliance: Tg^m4Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced G to A transition at base pair 66,758,006 (v38) on chromosome 15, or base pair 87,253 in the GenBank genomic region NC_000081 within the donor splice site of intron 36 (1-base pair from exon 36 [out of 48 total exons]). The effect of the mutation at the cDNA and protein levels has not been examined, but the mutation is predicted to result in skipping of the 135-base pair exon 36. The mutation would cause an in-frame deletion of 45 amino acids after amino acid 2,085; the wild-type protein is normally 2,766 amino acids in length. (J:272522)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tg Mutation: 147 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3854

References

• Original: J:272522 Zhong X, et al., Mutagenetix entry for samarai. MGI Direct Data Submission. 2019
• All: 1 reference(s)