Vav1^M3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Vav1^M3Btlr
• Name: vav 1 oncogene; mutation 3, Bruce Beutler
• MGI ID: MGI:6285507
• Synonyms: Belated
• Gene: Vav1 Location: Chr17:57586100-57635031 bp, + strand Genetic Position: Chr17, 29.76 cM
• Alliance: Vav1^M3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to T transversion at base pair 57,301,214 (v38) on chromosome 17, or base pair 22,136 in the GenBank genomic region NC_000083. The mutation corresponds to residue 1,059 in the mRNA sequence NM_011691 within exon 10 of 27 total exons. The mutation results in a threonine to serine substitution at amino acid 321 (R321S) in the VAV1 protein. (J:272527)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vav1 Mutation: 60 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3876

References

• Original: J:272527 Choi JH, et al., Mutagenetix entry for Belated. MGI Direct Data Submission. 2019
• All: 1 reference(s)