Dock8^M2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Dock8^M2Btlr
• Name: dedicator of cytokinesis 8; mutation 2, Bruce Beutler
• MGI ID: MGI:6285537
• Synonyms: Defenseless
• Gene: Dock8 Location: Chr19:24976898-25179796 bp, + strand Genetic Position: Chr19, 19.91 cM
• Alliance: Dock8^M2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to G transition at base pair 25,051,563 (v38) on chromosome 19, or base pair 52,053 in the GenBank genomic region NC_000085 encoding Dock8. The mutation corresponds to residue 252 in the mRNA sequence NM_028785 within exon 2 of 48 total exons. The mutation results in a threonine to alanine substitution at position 44 (T44A) in the DOCK8 protein. (J:272530)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dock8 Mutation: 103 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3734

References

• Original: J:272530 Zhong X, et al., Mutagenetix entry for Defenseless. MGI Direct Data Submission. 2019
• All: 1 reference(s)