Itgam^m3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Itgam^m3Btlr
• Name: integrin alpha M; mutation 3, Bruce Beutler
• MGI ID: MGI:6285549
• Synonyms: apparition
• Gene: Itgam Location: Chr7:127661812-127717663 bp, + strand Genetic Position: Chr7, 69.93 cM, cytoband F4
• Alliance: Itgam^m3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to G transition at base pair 128,112,286 (v38) on chromosome 7, or base pair 49,647 in the GenBank genomic region NC_000073 within the splice donor site of intron 17 (4-base pairs from exon 17 [out of 30 total exons]. The effect of the mutation at the cDNA and protein level have not examined, but the mutation is predicted to result in the use of a cryptic site in intron 17. The resulting transcript would have a 62-base pair insertion of intron 17, which would cause a frame-shifted protein product beginning after amino acid 720 of the protein (normally 1,154 amino acids in length) and termination after the inclusion of 18 aberrant amino acids. (J:272533)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgam Mutation: 48 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3758

References

• Original: J:272533 Zhong X, et al., Mutagenetix entry for apparition. MGI Direct Data Submission. 2019
• All: 1 reference(s)