Glul^tm1.1Ncd
Targeted Allele Detail

Summary

• Symbol: Glul^tm1.1Ncd
• Name: glutamate-ammonia ligase; targeted mutation 1.1, NC Danbolt
• MGI ID: MGI:6285753
• Synonyms: Glul^f
• Gene: Glul Location: Chr1:153775692-153785469 bp, + strand Genetic Position: Chr1, 65.43 cM, cytoband G2
• Alliance: Glul^tm1.1Ncd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272643
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129 x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A 5' loxP site was inserted in intron 1 at position 628 nucleotides 5' of exon 2, and the second 3' loxP site together with an frt-flanked PGK-neo selectable marker was inserted 140 nucleotides 5' of exon 7. Flp-mediated recombination removed the selection cassette, leaving exons 2-6 floxed. (J:272643)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glul Mutation: 35 strains or lines available

References

• Original: J:272643 Zhou Y, et al., Selective deletion of glutamine synthetase in the mouse cerebral cortex induces glial dysfunction and vascular impairment that precede epilepsy and neurodegeneration. Neurochem Int. 2019 Feb;123:22-33
• All: 1 reference(s)