Grp^tm1.1Zfc
Targeted Allele Detail

Summary

• Symbol: Grp^tm1.1Zfc
• Name: gastrin releasing peptide; targeted mutation 1.1, Zhou-Feng Chen
• MGI ID: MGI:6285757
• Synonyms: Grp^F
• Gene: Grp Location: Chr18:66005891-66019667 bp, + strand Genetic Position: Chr18, 38.98 cM
• Alliance: Grp^tm1.1Zfc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:288162
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 1, and an FRT-flanked neomycin selection cassette followed by a second loxP site downstream of exon 1 of the gene. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 1 floxed. (J:288162)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grp Mutation: 30 strains or lines available

References

• Original: J:288162 Barry DM, et al., Exploration of Sensory and Spinal Neurons Expressing GRP in Itch and Pain. bioRxiv. 2018
• All: 2 reference(s)