Ptprc^M10Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ptprc^M10Btlr
• Name: protein tyrosine phosphatase receptor type C; mutation 10, Bruce Beutler
• MGI ID: MGI:6285772
• Synonyms: Gyoza
• Gene: Ptprc Location: Chr1:137990599-138103446 bp, - strand Genetic Position: Chr1, 60.73 cM
• Alliance: Ptprc^M10Btlr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to T transversion at base pair 138,083,567 (v38) on chromosome 1, or base pair 92,190 in the GenBank genomic region NC_000067 encoding Ptprc. The mutation corresponds to residue 1,960 in the mRNA sequence NM_011210 within exon 19 of 30 total exons. The mutation results in an asparagine to isoleucine substitution at position 747 (N747I) in variant 1 of the CD45 protein, an N608I substitution in variant 2, and an N584I substitution in variant 3. (J:272777)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprc Mutation: 189 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3821

References

• Original: J:272777 Zhong X, et al., Mutagenetix entry for Gyoza. MGI Direct Data Submission. 2019
• All: 1 reference(s)