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PtprcM10Btlr
Chemically induced Allele Detail
Summary
Symbol: PtprcM10Btlr
Name: protein tyrosine phosphatase receptor type C; mutation 10, Bruce Beutler
MGI ID: MGI:6285772
Synonyms: Gyoza
Gene: Ptprc  Location: Chr1:137990599-138103446 bp, - strand  Genetic Position: Chr1, 60.73 cM
Alliance: PtprcM10Btlr page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Chemically induced (ENU) (Not Specified)
Mutation:    Single point mutation
 
Mutation detailsENU-induced A to T transversion at base pair 138,083,567 (v38) on chromosome 1, or base pair 92,190 in the GenBank genomic region NC_000067 encoding Ptprc. The mutation corresponds to residue 1,960 in the mRNA sequence NM_011210 within exon 19 of 30 total exons. The mutation results in an asparagine to isoleucine substitution at position 747 (N747I) in variant 1 of the CD45 protein, an N608I substitution in variant 2, and an N584I substitution in variant 3. (J:272777)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
 
Phenotypes:
Affected Systems
show or hide all annotated terms
 
hematopoietic system
decreased B-1b cell number
decreased IgE level
immune system
decreased B-1b cell number
decreased IgE level
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptprc Mutation:  189 strains or lines available
Notes
https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3821
References
Original:  J:272777 Zhong X, et al., Mutagenetix entry for Gyoza. MGI Direct Data Submission. 2019;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory