PtprcM10Btlr
Chemically induced Allele Detail
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Symbol: |
PtprcM10Btlr |
Name: |
protein tyrosine phosphatase receptor type C; mutation 10, Bruce Beutler |
MGI ID: |
MGI:6285772 |
Synonyms: |
Gyoza |
Gene: |
Ptprc Location: Chr1:137990599-138103446 bp, - strand Genetic Position: Chr1, 60.73 cM
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Alliance: |
PtprcM10Btlr page
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Allele Type: |
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Chemically induced (ENU) (Not Specified) |
Mutation: |
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Single point mutation
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Mutation details: ENU-induced A to T transversion at base pair 138,083,567 (v38) on chromosome 1, or base pair 92,190 in the GenBank genomic region NC_000067 encoding Ptprc. The mutation corresponds to residue 1,960 in the mRNA sequence NM_011210 within exon 19 of 30 total exons. The mutation results in an asparagine to isoleucine substitution at position 747 (N747I) in variant 1 of the CD45 protein, an N608I substitution in variant 2, and an N584I substitution in variant 3.
(J:272777)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | | |
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Phenotypes: |
Affected Systems |
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hematopoietic system
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decreased B-1b cell number
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decreased IgE level
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immune system
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decreased B-1b cell number
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√
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decreased IgE level
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ptprc Mutation: |
189 strains or lines available
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https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3821
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Original: |
J:272777 Zhong X, et al., Mutagenetix entry for Gyoza. MGI Direct Data Submission. 2019; |
All: |
1 reference(s) |
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