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Pcdhgem8Rwb
Endonuclease-mediated Allele Detail
Summary
Symbol: Pcdhgem8Rwb
Name: protocadherin gamma cluster; endonuclease-mediated mutation 8, Robert W Burgess
MGI ID: MGI:6285783
Synonyms: 1R1
Gene: Pcdhg  Location: unknown  Genetic Position: Chr18, Syntenic
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Modified isoform(s), Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele was generated through shotgun CRISPR/Cas9 editing using pooled sgRNAs that targeted each variable exon of the Pcdhg cluster and this allele was found to have a frameshift indel of exon C5 and a large rearrangement or deletion that encompasses almost all other variable exons from A1 through C3, leaving only exon C4 intact. (J:285314)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pcdhg Mutation:  13 strains or lines available
References
Original:  J:285314 Garrett AM, et al., CRISPR/Cas9 interrogation of the mouse Pcdhg gene cluster reveals a crucial isoform-specific role for Pcdhgc4. PLoS Genet. 2019 Dec;15(12):e1008554
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
08/02/2024
MGI 6.24
The Jackson Laboratory