Npm1^tm1Trow
Targeted Allele Detail

Summary

• Symbol: Npm1^tm1Trow
• Name: nucleophosmin 1; targeted mutation 1, Jennifer Trowbridge
• MGI ID: MGI:6285874
• Synonyms: Npm1^frt-cA
• Gene: Npm1 Location: Chr11:33102287-33113206 bp, - strand Genetic Position: Chr11, 19.21 cM
• Alliance: Npm1^tm1Trow page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272803
• Parent Cell Line: JM8A3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting vector contains an FRT site followed by PGK-puromycin, exon 11 of the mouse Npm1 gene, a polyA sequence, and a 4xSv40pA STOP cassette and a second FRT site inserted into the exon 10 intron, upstream of a humanized copy of exon 11 incorporating a TCTG frameshift duplication (p.W288fs*12; also called Npm1c Type A). (J:272803)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Npm1 Mutation: 36 strains or lines available

References

• Original: J:272803 Loberg MA, et al., Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis. Leukemia. 2019 Jan 28
• All: 1 reference(s)