Mlkl^M4Btlr
Chemically induced Allele Detail

Summary

• Symbol: Mlkl^M4Btlr
• Name: mixed lineage kinase domain-like; mutation 4, Bruce Beutler
• MGI ID: MGI:6285950
• Synonyms: Ghoulish
• Gene: Mlkl Location: Chr8:112038429-112064809 bp, - strand Genetic Position: Chr8, 57.98 cM, cytoband D3
• Alliance: Mlkl^M4Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 111,322,748 (v38) on chromosome 8, or base pair 15,709 in the GenBank genomic region NC_000074. The mutation corresponds to residue 1,126 in the mRNA sequence NM_001310613 within exon 5 of 11 total exons. The mutation results in a serine to proline substitution at position 248 (S248P) in the MLKL protein. (J:272831)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mlkl Mutation: 32 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3780

References

• Original: J:272831 Wang Y, et al., Mutagenetix entry for Ghoulish. MGI Direct Data Submission. 2019
• All: 1 reference(s)