Il2rb^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Il2rb^m2Btlr
• Name: interleukin 2 receptor, beta chain; mutation 2, Bruce Beutler
• MGI ID: MGI:6285957
• Synonyms: whistles
• Gene: Il2rb Location: Chr15:78363456-78379471 bp, - strand Genetic Position: Chr15, 37.52 cM, cytoband E
• Alliance: Il2rb^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to T transversion at base pair 78,481,936 (v38) on chromosome 15, or base pair 29,686 in the GenBank genomic region NC_000081 encoding Il2rb. The mutation corresponds to residue 1,309 in the mRNA sequence NM_008368 within exon 10 of 10 total exons. The mutation results in a tyrosine to phenylalanine substitution at position 387 (Y387F) in the CD122 protein. (J:272832)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il2rb Mutation: 45 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3753

References

• Original: J:272832 Yue T, et al., Mutagenetix entry for whistles. MGI Direct Data Submission. 2019
• All: 1 reference(s)