Dis3l2^em1Jtm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dis3l2^em1Jtm
• Name: DIS3 like 3'-5' exoribonuclease 2; endonuclease-mediated mutation 1, Joshua T Mendell
• MGI ID: MGI:6286049
• Synonyms: Dis3l1^delta11
• Gene: Dis3l2 Location: Chr1:86631530-86977817 bp, + strand Genetic Position: Chr1, 43.99 cM
• Alliance: Dis3l2^em1Jtm page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology deleted exon 11 resulting in a frameshift and premature termination codon and a null allele. Western blot analysis confirmed absence of protein in kidneys. (J:272435)

Disease models

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dis3l2 Mutation: 58 strains or lines available

References

• Original: J:272435 Hunter RW, et al., Loss of Dis3l2 partially phenocopies Perlman syndrome in mice and results in up-regulation of Igf2 in nephron progenitor cells. Genes Dev. 2018 Jul 1;32(13-14):903-908
• All: 1 reference(s)