Itgb2^M4Btlr
Chemically induced Allele Detail

Summary

• Symbol: Itgb2^M4Btlr
• Name: integrin beta 2; mutation 4, Bruce Beutler
• MGI ID: MGI:6286053
• Synonyms: Only_just
• Gene: Itgb2 Location: Chr10:77366164-77401542 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Itgb2^M4Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 77,549,968 (v38) on chromosome 10, or base pair 19,640 in the GenBank genomic region NC_000076. The mutation corresponds to residue 857 in the mRNA sequence NM_008404 within exon 7 of 16 total exons. The mutation results in a valine to alanine substitution at position 255 (V255A) in the integrin beta2 protein. (J:272843)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb2 Mutation: 50 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3760

References

• Original: J:272843 Zhong X, et al., Mutagenetix entry for Only_just. MGI Direct Data Submission. 2019
• All: 1 reference(s)