Itgb2^m5Btlr
Chemically induced Allele Detail

Summary

• Symbol: Itgb2^m5Btlr
• Name: integrin beta 2; mutation 5, Bruce Beutler
• MGI ID: MGI:6286064
• Synonyms: barely
• Gene: Itgb2 Location: Chr10:77366164-77401542 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Itgb2^m5Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced G to T transversion at base pair 77,548,536 (v38) on chromosome 10, or base pair 18,208 in the GenBank genomic region NC_000076 within intron 5, 10-base pairs from exon 6 (out of 16 total exons). The effect of the mutation at the cDNA and protein levels has not been examined, but the mutation is not predicted to affect splicing. If the mutation does affect splicing, the most likely aberrant splicing will result in the use of a cryptic site in intron 5. The resulting transcript would have a 54-base pair insertion of intron 5, which would cause a frame-shifted protein product beginning after amino acid 167 of the protein (normally 770 amino acids long) and termination after the inclusion of 34 aberrant amino acids. (J:272844)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb2 Mutation: 50 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3759

References

• Original: J:272844 Zhong X, et al., Mutagenetix entry for barely. MGI Direct Data Submission. 2019
• All: 1 reference(s)