Trp53bp1^m5Btlr
Chemically induced Allele Detail

Summary

• Symbol: Trp53bp1^m5Btlr
• Name: transformation related protein 53 binding protein 1; mutation 5, Bruce Beutler
• MGI ID: MGI:6286091
• Synonyms: split_pea
• Gene: Trp53bp1 Location: Chr2:121023762-121101888 bp, - strand Genetic Position: Chr2, 60.37 cM
• Alliance: Trp53bp1^m5Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU treatment induced an A-to-T transversion at base pair 121,228,606 (GRCm38) on chromosome 2, or base pair 61,720 in the GenBank genomic region NC_000068 encoding Trp53bp1. The mutation corresponds to residue 2,902 in the mRNA sequence NM_013735 within exon 13 of 28 total exons. The mutation results in substitution of arginine 925 with a stop codon (p.R925*) in the protein. (J:272848)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53bp1 Mutation: 100 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3861

References

• Original: J:272848 Zhong X, et al., Mutagenetix entry for split_pea. MGI Direct Data Submission. 2019
• All: 1 reference(s)