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ThemisM4Btlr
Chemically induced Allele Detail
Summary
Symbol: ThemisM4Btlr
Name: thymocyte selection associated; mutation 4, Bruce Beutler
MGI ID: MGI:6286098
Synonyms: Meteor
Gene: Themis  Location: Chr10:28544356-28759814 bp, + strand  Genetic Position: Chr10, 16.06 cM
Alliance: ThemisM4Btlr page
Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Mutation
description
Allele Type:    Chemically induced (ENU) (Not Specified)
Mutation:    Single point mutation
 
Mutation detailsENU-induced T to A transversion at base pair 28,781,832 (v38) on chromosome 10, or base pair 113,506 in the GenBank genomic region NC_000076 encoding Themis. The mutation corresponds to residue 1,154 in the mRNA sequence NM_178666 within exon 4 of 6 total exons. The mutation results in a valine to glutamic acid substitution at position 285 (V285E) in the Themis protein. (J:272849)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Themis Mutation:  57 strains or lines available
Notes
https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3866
References
Original:  J:272849 Zhong X, et al., Mutagenetix entry for Meteor. MGI Direct Data Submission. 2019;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory