Casp8^M2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Casp8^M2Btlr
• Name: caspase 8; mutation 2, Bruce Beutler
• MGI ID: MGI:6286116
• Synonyms: Porto
• Gene: Casp8 Location: Chr1:58834553-58886663 bp, + strand Genetic Position: Chr1, 29.19 cM, cytoband B
• Alliance: Casp8^M2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to A transversion at base pair 58,833,698 (GRCm38) on chromosome 1, or base pair 38,471 in the GenBank genomic region NC_000067 encoding caspase-8. The mutation corresponds to residue 1,125 in the mRNA sequence NM_009812, within 7 of 9 exons. The mutation results in a histidine to glutamine substitution at position 244 (H244Q) in the caspase-8 protein (isoform 1). (J:272851)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp8 Mutation: 45 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3723

References

• Original: J:272851 Zhong X, et al., Mutagenetix entry for Porto. MGI Direct Data Submission. 2019
• All: 1 reference(s)